Pandemic threat? Anyone else concerned?

Arjun

Known around here
Joined
Feb 26, 2017
Messages
9,095
Reaction score
11,139
Location
USA
That feeling when you realize your most recent bloodwork reports no circulating COVID-19 antibodies. Why you say? Because my last and only booster shot was in December 2021. Enough said :rofl:
 

Rob2020

Getting comfortable
Joined
Oct 2, 2020
Messages
991
Reaction score
2,565
Location
OR USA
Long but worth reading.

BY DANIEL HALPERIN

JANUARY 25, 2023 6:00 AM EST
Daniel Halperin, PhD is an epidemiologist based at the Gillings School of Global Public Health of the University of North Carolina, Chapel Hill. He has published over 60 peer reviewed articles on infectious diseases and is author of the book, Facing COVID Without Panic: 12 Common Myths and 12 Lesser Known Facts about the Pandemic.

A month before his recent retirement, Dr. Anthony Fauci cautioned that the U.S. “certainly” remains in the midst of a COVID pandemic. Other experts repeatedly warn of impending “deadly” waves caused by the latest genetic variants, and recently President Biden once again extended the COVID-19 Public Health Emergency. Yet those dire warnings hinge largely on an assumption that some 400 people in the U.S. continue dying daily from the disease. There are important reasons to question this assertion, as Dr. Leana Wen explored in the Washington Post. And if therefore in fact we’re no longer in a public health emergency (which a renowned virologist in Germany concluded last month), then some growing calls for reinstating school mask mandates or other inappropriate restrictions should be dropped.

For over a year, it has been apparent that many hospitalizations officially classified as being due to COVID-19 are instead of patients without COVID symptoms who are admitted for other reasons but also happen to test positive. Since nearly everyone is still routinely swabbed upon hospital admission (although the largest infection control organization has recommended against doing so), many patients with other conditions also receive a positive test result, especially during the ongoing Omicron surges—thereby overstating the number of hospitalizations tabulated as caused by COVID-19. UCLA researchers who examined Los Angeles County Public Hospital data discovered that over two-thirds of official COVID-19 hospitalizations since January 2022 were actually “with” rather than “for” the disease.

A rigorous Massachusetts assessment determined that a comparable proportion of COVID hospitalizations were in fact incidental to the coronavirus. An attending physician at Emory Decatur Hospital (and former president of Georgia’s chapter of the Infectious Diseases Society) cited by Dr. Wen estimates that some 90% of patients diagnosed with COVID at his hospital are now instead being treated for another illness. Wen also quoted Tufts Hospital’s epidemiologist, who similarly observes that recently the proportion of patients hospitalized for COVID-19 has been as low as 10% of the number reportedly having the disease. All this is fully consistent with the reality that by March 2022 over 95% of people had already been infected or vaccinated or typically both, and the resulting robust population immunity combined with the less virulent nature of Omicron results in far fewer severe outcomes.

Growing recognition of the overcounting of COVID-19 hospitalizations has caused some local authorities as well as the CDC to try to better estimate the actual levels. Misclassified hospitalizations obviously suggest there have also been miscategorized deaths, yet a parallel recognition that undoubtedly many official COVID-19 deaths are similarly due to persons dying with instead of from the coronavirus has only begun to emerge. CDC guidelines still stipulate that any death from (any) illness occurring within 30 days of a positive test result automatically be classified as due to COVID-19. Hence, if the current prevalence in the population is, say, 3% (towards the lower end of typical levels during major surges like the present one) then the background prevalence among persons admitted to hospitals for other reasons—and also among those who end up dying —would similarly be around 3%. Considering about 9,200 total deaths occur daily in the U.S., then in this hypothetical scenario some 275 deaths ascribed to COVID (or approximately two-thirds of the official daily count) would in fact have been due to other causes.

The former Milwaukee County chief medical examiner conducted a careful review of some 4,000 COVID-19 deaths reported during the pandemic there. His research revealed that nearly half had no link to COVID or in some cases only a “marginal” association, such as end stage cancer patients whose demise was possibly hastened by a few days or weeks, from catching the disease. An analysis of LA County and national data collected during the more recent waves of the highly contagious (but considerably less deadly) Omicron variants suggests that COVID-19 deaths are now likely being overcounted by at least fourfold. A newly published investigation from Denmark documented that, following the emergence of Omicron a year ago, an astonishing 65-75% of deaths officially attributed to COVID-19 have been merely incidental to the coronavirus, consistent with the above hypothetical exercise. Yet even if only half the currently reported deaths in the U.S. are not really caused by the virus, that would mean an actual daily COVID-19 toll of around 200, roughly the number dying during a bad flu season.

In addition to overcounted numbers of COVID hospitalizations and deaths, another reason for maintaining a public health emergency is the purportedly massive wave of ongoing long COVID. Yet almost all long COVID reports are based on tabulations of the number of persons who self-report lingering symptoms post-infection, rather than controlled studies that carefully compare the prevalence of persistent symptoms in persons who have been infected to those who have not. An announcement on San Francisco Bay Area Rapid Transit trains warns that any of a number of common maladies, including headaches, anxiety, diarrhea, muscle aches and trouble concentrating, may be caused by long COVID. But case control studies have so far found, at most, only modest differences in symptom prevalence comparing between persons previously infected or not (and new research suggests most symptoms dissipate within a year). While long COVID is undeniably a significant problem, as are those deaths still actually caused by the coronavirus, rigorous analysis is needed to more accurately estimate the prevalence.

The inadvertent exaggeration of COVID-19 deaths and long COVID leads not only to misplaced policy decisions, such as new mask mandates and booster recommendations for 6-month-old babies, but also to a needlessly enduring climate of fear, particularly in bluer regions (such as my hometown of San Francisco, where mask wearing remains commonplace, even outdoors). After three long years, it is past time to base public health pronouncements and policies on solid scientific evidence rather than well-meaning but often misleading assumptions.
 

wittaj

IPCT Contributor
Joined
Apr 28, 2019
Messages
24,884
Reaction score
48,532
Location
USA

bigredfish

Known around here
Joined
Sep 5, 2016
Messages
17,334
Reaction score
48,402
Location
Floriduh
Pfizer Responds After Director Says Company Is Developing Ways To Mutate COVID-19
(And YouTube takes down video)




Dr. Robert Malone, who helped develop the messenger RNA technology, said that the experiments Pfizer described met the definition of “gain of function.”

Pfizer is basically acknowledging that they are doing the same type of gain of function research that Boston University was caught doing, but they are denying that it is gain of function or directed evolution,” Malone wrote on Twitter.



In a notice sent to Project Veritas, YouTube cited its medical misinformation policy, which bars “claims about COVID-19 vaccination that contradict expert consensus from local health authorities or the World Health Organization (WHO).”

It wasn’t clear which authorities specifically YouTube was relying upon to rebut the video.

YouTube, which is owned by Google, did not respond to a request for comment.

O’Keefe noted that the claims in the video were made by a Pfizer director.

Project Veritas was given a “strike,” which prevents the organization from taking actions like uploading new videos for one week. A second strike would block such actions for two weeks and a third strike in a 90-day period would result in a permanent removal of the group’s account, YouTube warned.
 

bigredfish

Known around here
Joined
Sep 5, 2016
Messages
17,334
Reaction score
48,402
Location
Floriduh
FDA Quietly Changes End Date For Study Of Heart Inflammation After Pfizer COVID Vaccination

Pfizer was supposed to complete a study on the occurrence of subclinical myocarditis, or heart inflammation, after receipt of its COVID-19 vaccine. The completion date was listed by the FDA in 2021 as June 20, 2022. Pfizer was also supposed to submit the results of the study to the FDA by the end of 2022 as part of a list of requirements the FDA imposed as a condition of approving Pfizer’s jab.

But after the deadline passed, the FDA quietly changed the date.

Under a list of postmarketing requirements for the Pfizer-BioNTech vaccine, the FDA now says the same study has an “original projected completion date” of June 30, 2023.

The current status of the study is listed as “pending.”

The FDA and Pfizer did not respond to requests for comment.

Jessica Adams, a former regulatory review officer at the FDA, said the wording amounts to misinformation.

“By definition, ‘original’ dates can’t change,” she wrote on Twitter, tagging the agency. “Please correct this ‘misinformation.'”

Most of the meeting presentations that went over adverse events focused on ischemic stroke, which triggered the threshold for a safety signal following Pfizer’s bivalent booster in the elderly and following receipt the original Pfizer and Moderna vaccines in all adults.

Officials said that the stroke has happened in many people who received a flu vaccine on the same day as a COVID-19 vaccine. They’re studying whether there’s a connection, though they noted there was no signal for the stroke after a flu shot alone.

Dr. Nicola Klein, a Kaiser Permanente researcher who helps the CDC monitor vaccine safety, said that the signal for stroke wasn’t as strong as that for myocarditis.

“This is a cluster but … it doesn’t stand out as extremely striking, unlike some other signals which we have seen,” Klein said. “For example, myocarditis, it’s an extremely strong signal that you can see without doing statistics.”
 

Rob2020

Getting comfortable
Joined
Oct 2, 2020
Messages
991
Reaction score
2,565
Location
OR USA
This is going to get some attention both positive and negative.

The role of social circle COVID-19 illness and vaccination experiences in COVID-19 vaccination decisions: an online survey of the United States population

  • Published: 24 January 2023


Abstract
Background
Around the world, policymakers have clearly communicated that COVID-19 vaccination programs need to be accepted by a large proportion of the population to allow life return to normal. However, according to the Center for Disease Control, about 31% of the United States population had not completed the primary vaccination series as of November 2022.
Aims
The primary aim of this work is to identify the factors associated by American citizens with the decision to be vaccinated against COVID-19. In addition, the proportion of fatal events from COVID-19 vaccinations was estimated and compared with the data in the VAERS database.
Methods
An online survey of COVID-19 health experiences was conducted. Information was collected regarding reasons for and against COVID-19 inoculations, experiences with COVID-19 illness and COVID-19 inoculations by survey respondents and their social circles. Logit regression analyses were carried out to identify factors influencing the likelihood of being vaccinated.
Results
A total of 2840 participants completed the survey between December 18 and 23, 2021. 51% (1383 of 2840) of the participants were female and the mean age was 47 (95% CI 46.36–47.64) years. Those who knew someone who experienced a health problem from COVID-19 were more likely to be vaccinated (OR: 1.309, 95% CI 1.094–1.566), while those who knew someone who experienced a health problem following vaccination were less likely to be vaccinated (OR: 0.567, 95% CI 0.461–0.698). 34% (959 of 2840) reported that they knew at least one person who had experienced a significant health problem due to the COVID-19 illness. Similarly, 22% (612 of 2840) of respondents indicated that they knew at least one person who had experienced a severe health problem following COVID-19 vaccination. With these survey data, the total number of fatalities due to COVID-19 inoculation may be as high as 278,000 (95% CI 217,330–332,608) when fatalities that may have occurred regardless of inoculation are removed.
Conclusion
Knowing someone who reported serious health issues either from COVID-19 or from COVID-19 vaccination are important factors for the decision to get vaccinated. The large difference in the possible number of fatalities due to COVID-19 vaccination that emerges from this survey and the available governmental data should be further investigated.

 
Top